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PMID: 8017015.

Given the limitations of the in vitro model using one human adipocyte cell line, further studies are necessary to confirm the hypothesis that nutrients, by stimulating the secretion of GLP-1, may influence the expression of irisin and thus modulate the mitochondrial metabolism of adipocytes.

This article compares those pathways using FDA and manufacturer disclosures and platform terms as of December 26, 2025